Can You Run Malwarebytes With Another Anti Virus Or Anti Spyware Program Already On Your Computer?

I’m thinking about ditching Windows Defender because I know it sucks, and it came with Norton Internet Security 2008, and I know I have talked bad about Norton, but they have improved greatly from the past, and it doesn’t slow my laptop.
I’ve read and heard so many great reviews about it, so if I have Norton, Super anti spyware, can I run malwarebytes along with them?

How Do I Delete Firewalls On Norton Internet Security?

I’ve read the help and support thing but the instructions are unclear and I don’t know where the General or Secondary Rules thing is. Thanks in advance xo