Can You Run Malwarebytes With Another Anti Virus Or Anti Spyware Program Already On Your Computer?

I’m thinking about ditching Windows Defender because I know it sucks, and it came with Norton Internet Security 2008, and I know I have talked bad about Norton, but they have improved greatly from the past, and it doesn’t slow my laptop.
I’ve read and heard so many great reviews about it, so if I have Norton, Super anti spyware, can I run malwarebytes along with them?